• 0 Posts
  • 24 Comments
Joined 1 year ago
cake
Cake day: July 1st, 2023

help-circle

  • OP, I’d urge you to reconsider framing this whole thing as an “extrovert vs introvert” battle. Your boss is demonstrating poor boundaries and disrespectful and inappropriate behavior, and that has nothing to do with whether she’s an I or E on the Myers-Briggs.

    Whether or not you go to HR depends a lot on your company culture. Either way, you need to be documenting specific comments and specific behaviors that are inappropriate first. Every time she asks you an uncomfortable question, especially if it relates to sex, write down what she asked, how you responded (that you declined to answer and asked her to stop asking personal questions), who else was present, and the date/time. Keep this in a personal account, not company. Do NOT go to HR without documentation.

    We don’t know how big your company is, but odds are if she’s a middle manager she’s got people above her already who know she’s a gossip and hate that. If you have any relationship at all with her supervisor, it’s generally viewed as following the chain of command if you bring concerns like this directly to them, as well.



















  • This is pretty easy to search, but also intuitive when you consider crack is most often smoked vs cocaine being absorbed through your nasal mucosa. Here are a few highlights from this comprehensive review, which also covers the very real socioeconomic differences in use patterns:

    By virtue of its hydrophilicity, cocaine hydrochloride is generally consumed by ‘snorting.’ ‘Crack’ cocaine is generally the only form of cocaine that is smoked—this is due to the fact that cocaine hydrochloride has an elevated boiling point and does not vaporise at the temperatures of combustion.

    ®outes that involve the respiratory system…allow for the stimulant to reach the brain circulation in around 6 to 8 s; the inhalation route presents higher peak plasma concentrations that are reached faster when compared to intranasal administration. It should be noted that, for the intranasal route, the vasoconstrictive properties of cocaine slow down the drug’s own absorption, causing a 60-min delay of peak plasmatic concentrations. In terms of bioavailability, the inhalation route has the greatest bioavailability, which surpasses 90%, while the intranasal route has roughly 80%.

    The abuse and dependence of cocaine is strongly related to the drug’s capacity to induce the release of dopamine within the mesocorticolimbic circuit (also known as the reward system). As the user continues to consume cocaine, desensitization occurs and so larger doses are necessary to induce stimuli of the same magnitude as before, as well as to minimize withdrawal symptoms.

    Another difference of inhalation vs intranasal:

    Smoking ‘crack’ leads to the formation of another biomarker of exposure, AEME, which is the main product of cocaine’s thermal degradation. In vitro and in vivo studies show that AEME appears to have effects on the cardiovascular system, by acting as a muscarinic agonist. Furthermore, neurotoxic effects were also reported for this metabolite.