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An isle seat.
Before you get on your flight, get a bottle of water and chug it as fast as you comfortably can. Have another one to drink throughout the flight. This keeps swelling of your hands and feet down. You’ll have to get up and pee a lot, which is why an isle seat is a good idea, but you’ll be so much more comfortable during and after the flight.
But remember water at the airport is quite expensive. So if the airport has refill stations get a small bottle and refill. Also when you board just directly take of your shoes. And bring some warmer clothes if you easily feel cold.
Other option is to empty your bottle before going through security and fill it back after. Keep the bottle and do it every time and you will always have water.